Sedator Injection For mild to heavy sedation and for analgesia and control of pain in uncomplicated colic.


Detomidine Hydrochloride 10 mg/mL


5mL Single vial
20mL vial


Sedator is a dose controlled sedative and analgesic. It may be used to facilitate examinations, x-rays, minor surgical procedures, transport etc. It may be used to control pain including that of the uncomplicated equine colic case. Sedator has a role in providing prolonged analgesia (up to 12 hours) in horses for example with an accident case. Sedator is a sedative and analgesic that may be used to facilitate:

• Examinations e.g. endoscopy, rectal palpation, gynaecological examinations & x-rays.

• Minor surgical procedures e.g. treatment of wounds, removal of skin tumours, hoof care and castration.

• Pre-anaesthetic agent.

• Treatment and medication e.g. use of nasogastric tube, clipping and shoeing.

• In painful procedures detomidine should be used in combination with an analgesic or a local anaesthetic.

• Effective analgesia in treatment of colic cases and management of serious injuries.

• Dental examinations and procedures.


Intravenous potentiated sulphonamides are contraindicated in sedated or anaethetised horses as potentially fatal dysrhythmias may occur. Sedator is not recommended for use in pregnant mares.


Sedator may cause penile relaxation. Use with caution on male animals, particularly stallions during the breeding season. Clinicians should anticipate the tendency of the animal’s head to drop under the influence of Sedator and the subject should be accommodated appropriately. Immediately following administration there may be a tendency to stagger, particularly if high dose rates are employed. Because of the risk of oesaphageal choke, the animal should not be fed until the effect of the drug has worn off. The safe handling of horses can be improved with Sedator. Although the animal is easy to handle under Sedator sedation, normal precautions are recommended. Local anaesthetics should be used when required for painful procedures, particularly surgery, as the duration of analgesia from Sedator may not equate with the duration of sedation. A risk/benefit assessment should be undertaken by a veterinarian before using this product in animals suffering from cardiac disease (with pre-existing bradycardia and risk of atrioventricular block), respiratory, liver or renal insufficiencies or shock.

Overdosage and side effects: The symptoms may be relieved by atropine or a specific alpha-2 antagonist. Sympathomimetic properties, particularly at higher doses, may include piloerection, sweating, diuresis & occasional slight tremors.


Use contents within 11 weeks of first broaching vial. Discard the unused portion.

Dosage: 0.1 mL to 0.8 mL IM or IV per 100 kg bodyweight depending on desired depth and duration of effect. Administration is by slow intravenous or the intramuscular route. For analgesia in COLIC until diagnosis is confirmed, recommended dose is 20-40 μg/kg BW (0.2-0.4 mL/100 kg BW).

The full analgesic effect is established by 5-15 minutes following administration. If the desired level of sedation is not achieved following administration of a low dose, a further additive dose may be given. The dose response can be graded from I to III as follows:


Detomidine (in Sedator) is a centrally active alpha-2 adrenergical agonist, similar in its pharmacology to clonidine. Sedator is a potent preparation and any accidental spillage etc. should be promptly washed off. Accidental administration to humans may produce hypertension of variable duration which may be followed by hypotension. First stage aid should include careful monitoring of the blood pressure with administration of phentolamine if dangerous levels of hypertension develop. Hypotension should be treated with fluid replacements and other supportive measures.


DO NOT USE in horses that may be used for human consumption.


If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.


If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131126 or in New Zealand 0800 764 766.


Dispose of empty container or expired product by wrapping with paper and putting in garbage.


Store below 25°C (air conditioning). Protect from light. Do not freeze.


APVMA Approval No. 82623/106271

ACVM No. A011244 (New Zealand)

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